A 2025 study introduces the “Aging Spiral Hypothesis” — the theory that mitochondrial decline is not a consequence of aging, but its primary trigger. As mitochondrial function decreases, cellular energy falls, repair slows, and the visible aging process accelerates. The research demonstrates that this decline begins in the epidermis earlier than previously understood, making proactive mitochondrial support essential — not reactive.
Feb 26, 2026
Journal of Investigative Dermatology — ScienceDirect | 2025
